Comparison 2. Any pharmacologic intervention vs. placebo given in addition to psychosocial intervention among participants with alcohol use disorder.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Harmful alcohol use (continuous)	4	475	Std. Mean Difference (IV, Random, 95% CI)	‐0.43 [‐0.61, ‐0.24]
2.2 Harmful alcohol use (dichotomous)	1	102	Risk Ratio (M‐H, Random, 95% CI)	0.62 [0.16, 2.47]
2.3 Alcohol consumption	1	71	Std. Mean Difference (IV, Random, 95% CI)	0.34 [‐0.13, 0.81]
2.4 Remission	4	462	Risk Ratio (M‐H, Random, 95% CI)	1.19 [1.01, 1.40]
2.5 Retention	3	363	Risk Ratio (M‐H, Random, 95% CI)	1.15 [0.95, 1.40]
2.6 Adverse events	0		Other data	No numeric data