Fig. 7. Ponericins adopt an α-helical conformation in lipid-like environments.
CD spectra of synthetic ponericins (25 μM) dissolved in (A) ultrapure water, (B) 20% TFE, and (C) 20 mM SDS. Α-Helical wheel projections generated using NetWheels (35] for (D) Na1b; (E) Nc1a; (F) Nc2a; (G) Nc3a (N-tenninal, Gl-Pl8); (H) Nc3a CC-terminal El9-N30); and (I) Nc3b. Two wheels are shown for Nc3a representing the regions either side of a proline residue, which is likely to disrupt helicity.
