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. Author manuscript; available in PMC: 2023 May 9.
Published in final edited form as: Biochem Pharmacol. 2021 Jul 22;192:114693. doi: 10.1016/j.bcp.2021.114693

Table 2. Antimicrobial activity of ponericins.

Minimum inhibito1y concentrations (MIC, μM) of synthetic ponericins, colistin, and vancomycin against Gram negative and Gram-positive bacterial pathogens from the genera Escherichia, Klebsiella, Acinetobacter, Pseudomonas, Staphylococcus and Bacillus. MIC values below 3 μM are shown in bold and shaded.

Minimum inhibitory concentration (μM)

Na1b Nc1a Nc2a Nc3a Nc3b Colistin Vancomycin

E.coli ATCC 5.9–11.8 25.8–51.6 11.7–46.9 2.3–4.7 >40 0.02–0.11
259922

K. pneumoniae 23.7–47.4 >40 >40 5.9–11.8 >40 0.02–0.11
ATCC 13883

A. baumannii 1.4–2.9 12.91 23. 7–47.4. 1.48 >40 0.11
ATCC 19606

P. aeruginosa >40 >40 >40 11.8 – 23.7 >40 0.22–0.43
ATCC 27853

S. aureus 0.3–5.9 2.9–5.9 >40 23.7–47.4 >40 0.69–1.38
ATCC 43300

B. subtilis 0.18–2.9 1.48–5.9 5.9–11.8 1.48–2.9 >40 0.17–0.35
ATCC 6051