Table 2. Antimicrobial activity of ponericins.
Minimum inhibito1y concentrations (MIC, μM) of synthetic ponericins, colistin, and vancomycin against Gram negative and Gram-positive bacterial pathogens from the genera Escherichia, Klebsiella, Acinetobacter, Pseudomonas, Staphylococcus and Bacillus. MIC values below 3 μM are shown in bold and shaded.
| Minimum inhibitory concentration (μM) | |||||||
|---|---|---|---|---|---|---|---|
|
|
|||||||
| Na1b | Nc1a | Nc2a | Nc3a | Nc3b | Colistin | Vancomycin | |
|
| |||||||
| E.coli ATCC | 5.9–11.8 | 25.8–51.6 | 11.7–46.9 | 2.3–4.7 | >40 | 0.02–0.11 | – |
| 259922 | |||||||
|
| |||||||
| K. pneumoniae | 23.7–47.4 | >40 | >40 | 5.9–11.8 | >40 | 0.02–0.11 | – |
| ATCC 13883 | |||||||
|
| |||||||
| A. baumannii | 1.4–2.9 | 12.91 | 23. 7–47.4. | 1.48 | >40 | 0.11 | – |
| ATCC 19606 | |||||||
|
| |||||||
| P. aeruginosa | >40 | >40 | >40 | 11.8 – 23.7 | >40 | 0.22–0.43 | – |
| ATCC 27853 | |||||||
|
| |||||||
| S. aureus | 0.3–5.9 | 2.9–5.9 | >40 | 23.7–47.4 | >40 | – | 0.69–1.38 |
| ATCC 43300 | |||||||
|
| |||||||
| B. subtilis | 0.18–2.9 | 1.48–5.9 | 5.9–11.8 | 1.48–2.9 | >40 | – | 0.17–0.35 |
| ATCC 6051 | |||||||