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Comparison of total and internalized (resistant to gentamicin in single cell suspensions of lung) noncytotoxic P. aeruginosa PAO1 (left) and cytotoxic P. aeruginosa 6077 (right) cells at the indicated times after application to the nares of anesthetized mice. Bars represent the mean CFU, and the error bars show the standard deviations. The inoculum for P. aeruginosa PAO1 was 3 × 108 CFU/nose; the inoculum for P. aeruginosa 6077 was 3 × 106 CFU/nose.
