TABLE 1.
LD50 values after 72 h of infection comparing three strains of P. aeruginosa carrying either pUCP19 or pUCP19exoUspcU after intranasal application to anesthetized mice
| P. aeruginosa strain | Plasmid | LD50 CFU | Pa |
|---|---|---|---|
| PAO1 | pUCP19 | 2.8 × 107 | |
| pUCP19exoUspcU | 7.1 × 105 | 0.047 | |
| PAO6ad | pUCP19 | 2.2 × 107 | |
| pUCP19exoUspcU | 1.4 × 106 | 0.0001 | |
| 15921 | pUCP19 | >108b | |
| pUCP19exoUspcU | 3.6 × 106 | 0.0001 |
a
P was determined by logistic regression for parallel bioassays.
b
The LD50 for 15921(pUCP19) could not be calculated since the maximal dose applied of 109 CFU/mouse caused insufficient mortality.