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. 2023 May 5;17:1357–1369. doi: 10.2147/DDDT.S405450

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© 2023 Wang et al.

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The UBE2T inhibitor, M435-1279, increases TMZ sensitivity in GBM cells. (A) U251 and U87 cells were treated with the indicated concentrations of M435-1279 (0, 1, 2, 5, 10, 20, 50, 100 μM) for 48 h and cell survival rate determined by CCK-8 assay. (B) U251 and U87 cells were treated with 10 μM M435-1279 for 24, 48, 72, and 96 h and cell survival rate determined by CCK-8 assay. (C) U251 and (D) U87 cells were treated with the indicated concentrations of TMZ (0, 10, 25, 50, 100, 200, 400, 800 μM) in combination with or without M435-1279 (5 μM) for 72 h and cell survival rate determined by CCK-8 assay. (E) U251 and U87 cells were treated with TMZ (20 μM) in combination with or without M435-1279 (2 μM) for 3–7 days. (F) Colony formation efficiency was determined by colony formation assay. n = 3, *P < 0.05, **P < 0.01, compared with the indicated group.