TABLE II.

Descriptive Statistics, 95% CIs, and Superiority and Non-Inferiority Designations for 6 Commonly Used Irrigation Solutions Tested on Chondrosarcoma Cells in Vitro at 2 and 5-Minute Durations^*

	Cytotoxicity (%)				Test of Superiority to LCC		Test of Non-Inferiority to HCC
Solution and Duration	Mean	SE	95% CI		P Value	Conclusion†	P Value	Conclusion†
2 minutes
0.9% saline solution	0.93	2.10	−3.84	5.70	0.002	Non-superior	<0.001	Inferior
H2O	18.37	4.45	8.56	28.19	0.087	Indeterminate	<0.001	Inferior
3% H2O2	7.15	2.58	1.45	12.84	0.29	Indeterminate	<0.001	Inferior
70% EtOH	5.33	1.82	1.42	9.23	0.022	Non-superior	<0.001	Inferior
0.3% PVP-I	−2.45	1.65	−6.08	1.18	<0.001	Non-superior	<0.001	Inferior
0.05% CHG	128.73	20.21	77.22	180.24	0.002	Superior	0.11	Indeterminate
5 minutes
0.9% saline solution	−7.72	1.23	−10.61	−4.84	<0.001	Non-superior	<0.001	Inferior
H2O	37.04	5.47	23.11	50.98	0.004	Superior	<0.001	Inferior
3% H2O2	15.11	9.97	−10.41	40.64	0.63	Indeterminate	<0.001	Inferior
70% EtOH	−5.00	3.06	−12.37	2.38	0.002	Non-superior	<0.001	Inferior
0.3% PVP-I	−24.06	1.32	−27.33	−20.79	<0.001	Non-superior	<0.001	Inferior
0.05% CHG	99.35	1.84	94.79	103.92	<0.001	Superior	0.003	Non-inferior

^*Classification rules are shown in Table I. The mean and CI of the cytotoxicity percentage for each irrigation solution are plotted in Figure 2. SE = standard error, CI = confidence interval, LCC = low-cytotoxicity control, HCC = high-cytotoxicity control, EtOH = ethanol, PVP-I = povidone-iodine, CHG = chlorohexidine gluconate.

^†See Table I for rules for determining conclusions based on the 95% CI.