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[Preprint]. 2023 Apr 29:2023.04.28.538728. [Version 1] doi: 10.1101/2023.04.28.538728

Figure 2: Amyloid- and microglia-dependent spine plasticity in oblique branches from B6 but not PWK mice.

Figure 2:

(A) Oblique dendritic lengths (left) and branch points (right). Individual data points represent each reconstructed neuron (n=3–5/mouse); error bars are ± SD; asterisks denote post-hoc (p<0.05) after two-way ANOVA and corrections for multiple comparisons.

(B) Example deconvolved confocal image of an EGFP+ oblique branch. Spine density was acquired across dendrites (left) and individual spines measured for maximum head diameter (right).

(C) Oblique branch spine densities across genotype/treatment groups. Data points represent individual branches (n=10–15/mouse); error bars are ± SD; asterisks denote comparisons (p<0.05) identified between control and PLX5622 groups after two-way ANOVA and corrections for multiple comparisons.

(D) Spine head diameter cumulative distributions from B6 (left) and PWK (right). Kolmogorov-Smirnov (K-S) tests were used to evaluate statistical significance (see Table S3).

Statistical analyses performed on B6 and PWK separately. For (A) and (C) *adjusted p<0.05 Bonferroni post-hoc tests (Table S3).