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[Preprint]. 2023 Apr 27:2023.04.27.538511. [Version 1] doi: 10.1101/2023.04.27.538511

Figure 3: Optogenetic circuit mapping reveals that postsynaptic targets of Sst-INs are subpopulation-specific.

Figure 3:

A, Voltage-clamp recordings (holding potential, 0 mV) from pyramidal cells, fast-spiking interneurons and regular-spiking interneurons with prominent sag, showing representative IPSCs generated by optogenetic activation of IN subpopulations. B, Summary bar graph of IPSC amplitudes recorded in the three target types. The dotted red lines show the arithmetic sums of IPSCs generated by photostimulation of the individual subpopulations. C, Sequential recordings from neighboring fast-spiking interneurons and pyramidal cells reveals target-specificity of Sst;;Tac1-INs, Ndnf;;Nkx2–1-INs and Chrna2-INs. D, Cartoon depicting the target selectivity of Sst-IN subpopulations.