Table 2:
Associations between MAPT haplotypes and risk of Pick’s disease.
| MAPT variant | Haplotype frequency (%) | Association with Pick’s disease | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Haplotype | rs1467967 | rs242557 | rs3785883 | rs2471738 | rs8070723 | rs7521 | Pick’s disease patients (N=338) | Controls (N=1312) | OR (95% CI) | P-value |
| H1b | G | G | G | C | A | A | 13.1 | 16.0 | 0.76 (0.58, 1.00) | 0.051 |
| H1c | A | A | G | T | A | G | 10.2 | 11.3 | 0.93 (0.70, 1.25) | 0.65 |
| H1d | A | A | G | C | A | A | 7.4 | 7.1 | 0.99 (0.68, 1.42) | 0.94 |
| H1e | A | G | G | C | A | A | 9.8 | 9.0 | 1.03 (0.74, 1.42) | 0.87 |
| H1f | G | G | A | C | A | A | 0.0 | 1.2 | N/A1 | 0.049 |
| H1g | G | A | A | C | A | A | 0.7 | 1.1 | 0.43 (0.11, 1.65) | 0.22 |
| H1h | A | G | A | C | A | A | 4.0 | 4.1 | 0.95 (0.57, 1.57) | 0.85 |
| H1i | G | A | G | C | A | A | 3.9 | 4.4 | 0.98 (0.60, 1.61) | 0.95 |
| H1l | A | G | A | C | A | G | 3.6 | 3.0 | 1.11 (0.67, 1.84) | 0.69 |
| H1m | G | A | G | C | A | G | 2.9 | 2.9 | 1.00 (0.56, 1.78) | 0.99 |
| H1o | A | A | A | C | A | A | 1.1 | 2.3 | 0.53 (0.23, 1.26) | 0.15 |
| H1p | G | G | G | T | A | G | 1.1 | 1.5 | 0.82 (0.33, 2.04) | 0.66 |
| H1r | A | G | G | T | A | G | 0.7 | 1.1 | 0.63 (0.20, 2.01) | 0.44 |
| H1u | A | A | G | C | A | G | 2.4 | 2.4 | 1.11 (0.58, 2.11) | 0.75 |
| H1v | G | G | A | T | A | G | 2.2 | 1.2 | 1.50 (0.70, 3.21) | 0.30 |
| H1x | G | A | A | T | A | G | 1.3 | 1.3 | 1.06 (0.44, 2.56) | 0.91 |
| H1y | A | A | A | T | A | G | 1.4 | 1.6 | 0.85 (0.34, 2.07) | 0.71 |
| H2 | A | G | G | C | G | G | 28.5 | 22.7 | 1.34 (1.11, 1.63) | 0.0028 |
ORs, 95% CIs, and p-values result from score tests of association that were adjusted for age and sex.
1
Indicates a haplotype that was not observed in Pick’s disease patients, making estimation of an OR impossible. P-values <0.0028 are considered as statistically significant after applying a Bonferroni correction for multiple testing. OR=odds ratio; CI=confidence interval.