Table 3:

Associations of MAPT haplotype with age of disease onset and disease duration in Pick’s disease cases.

		Association with age of disease onset		Association with disease duration
Haplotype	Haplotype frequency (%), N=309	β (95% CI)	P-value	β (95% CI)	P-value
H1b	13.3%	2.66 (0.63, 4.70)	0.011	−0.03 (−1.07, 1.02)	0.96
H1c	10.0%	1.63 (−0.61, 3.86)	0.15	0.08 (−1.05, 1.22)	0.88
H1d	7.2%	0.79 (−1.79, 3.38)	0.55	−0.91 (−2.21, 0.39)	0.17
H1e	9.3%	0.52 (−1.94, 2.98)	0.68	0.52 (−0.72, 1.76)	0.41
H1h	4.0%	2.03 (−1.57, 5.64)	0.27	−0.45 (−2.27, 1.37)	0.63
H1i	4.1%	−3.66 (−6.83, −0.48)	0.025	−0.90 (−2.53, 0.72)	0.28
H1l	3.5%	−1.75 (−5.42, 1.92)	0.35	0.43 (−1.42, 2.28)	0.65
H1m	3.1%	−1.25 (−5.33, 2.84)	0.55	0.94 (−1.11, 3.00)	0.37
H1o	1.2%	0.05 (−6.91, 7.00)	0.99	0.03 (−3.47, 3.52)	0.99
H1p	1.0%	−5.65 (−12.60, 1.30)	0.11	0.17 (−3.36, 3.69)	0.93
H1u	2.2%	−5.25 (−10.42, −0.07)	0.048	−2.40 (−5.03, 0.22)	0.074
H1v	2.1%	−1.74 (−6.61, 3.13)	0.48	1.91 (−0.54, 4.35)	0.13
H1x	1.4%	−5.39 (−11.84, 1.07)	0.10	−3.73 (−6.98, −0.48)	0.025
H1y	1.5%	−0.70 (−6.93, 5.54)	0.83	1.82 (−1.31, 4.95)	0.26
H1z	1.6%	−1.81 (−8.02, 4.40)	0.57	−0.08 (−3.20, 3.05)	0.96
H2	29.4%	−0.62 (−2.03, 0.79)	0.39	0.22 (−0.49, 0.93)	0.54

β values, 95% CIs, and p-values result from score tests of association that were adjusted for sex and series (age of disease onset analysis) or sex, age of disease onset, and series (disease duration analysis). β values are interpreted as the change in the mean value of the given outcome (age of disease onset or disease duration) corresponding to each additional copy of the given haplotype. P-values <0.0031 are considered as statistically significant after applying a Bonferroni correction for multiple testing. β=regression coefficient; CI=confidence interval.