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[Preprint]. 2023 Sep 6:2023.04.29.538828. Originally published 2023 Apr 29. [Version 2] doi: 10.1101/2023.04.29.538828

Fig. 8: Sub-clustering of endothelial and epithelial cells.

Fig. 8:

(A) UMAP of endothelium and epithelium CLUs used for sub-clustering. (B) UMAP of endothelium/epithelium SCLs. (C) Dot plot of markers used for SCL celltype identification. (D) Z-scores indicating activation or inhibition of pathways altered with aging by IPA analysis in vascular endothelial cells. (E) Z-scores indicating activation or inhibition of upstream regulators during aging by IPA analysis in endothelium/epithelium SCLs. (F) Z-scores indicating up or downregulation of genes by TP35, Cdkn1a and Cdkn2a genes. (G) Dot plot of expression of cell senescence markers in vascular endothelial cells in 3- and 9-month-old ovaries. scRNA-seq was performed in n=4 ovaries/age.