Figure 5.

Extracellular field potentials measured from the stratum radiatum of the hippocampus in Slc1a4^K/K and wildtype mice. (A) Sample traces showing representative field responses in hippocampal slices from wildtype (left, dark traces) or Slc1a4^K/K (right, light traces) mice, evoked by paired stimuli in stratum radiatum (50 ms interpulse interval). (B) Input/output relationship, showing the peak amplitude of the first EPSP plotted as a function of stimulus strength. (C) The average paired pulse facilitation ratio, taken as the peak amplitude-2/amplitude-1, shows no statistically significant differences in this form of short facilitation. (D) Synaptic plasticity was assessed by theta burst stimulation (TBS 1x) in the stratum radiatum. The time series measuring the first pea amplitude shows a 10-minute baseline, then enhanced synaptic response following the TBS. The inset shows the average long-term potentiation (LTP) taken 30-min post-TBS stimulation for the two genotypes.