Figure 2: Polygenic scores across those who have and have not reported a suicide attempt.

Panel A presents odds ratios (OR) for AUD, DEP, and SUI PGSs from logistic regression models in persons with AUD who had and had not attempted suicide. Panel B presents OR from multinomial logistic models (no AUD, no suicide attempt as reference group). All models include cohort, sex, PC1-PC3, array, and site as covariates. SEs adjusted for familial clustering using cluster-robust standard errors. AFR = African-like genetic similarity grouping, EUR = European like genetic similarity grouping, AUD = alcohol use disorder polygenic score, DEP = depression polygenic score, = SUI suicide attempt polygenic score, SA− = no lifetime suicide attempt, AUD− = does not meet criteria for alcohol use disorder, SA+ = lifetime suicide attempt, AUD+ = meets criteria for alcohol use disorder.