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. 2023 May 4;83(9):1393–1411.e7. doi: 10.1016/j.molcel.2023.03.018

Figure 3.

Figure 3

JARID2 promotes CBX7-cPRC1 while MTF2 promotes CBX4-cPRC1 recruitment to Polycomb target genes in ESCs

(A) Schematic of PRC2.1 or PRC2.2 rescue strategy in QKO ESCs.

(B) Western blot analyses of the indicated antibodies on total protein extracts from QKO ESC rescue lines, described in (A).

(C) Average and tornado plots showing ChIP-Rx enrichments of indicated antibodies at maintained Polycomb targets (n = 2,175) in the relevant cell lines.

(D) Genome browser tracks showing ChIP-Rx enrichments of indicated antibodies in the relevant cells at the extended HoxA locus.

(E) Average plot showing ChIP-Rx and ChIP-seq enrichments of indicated antibodies at maintained Polycomb target genes (n = 2,175) in the relevant cell lines.

(F) Genome browser tracks showing ChIP-Rx and ChIP-seq enrichments of indicated antibodies in the relevant cell lines at the Pitx1 locus.

See also Figure S3.