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. Author manuscript; available in PMC: 2023 May 9.
Published in final edited form as: Trends Biochem Sci. 2019 Oct 17;45(1):13–26. doi: 10.1016/j.tibs.2019.09.003

Figure 3(key figure): A model for catalyzed nucleosome-unwrapping facilitating TF-binding.

Figure 3(key figure):

A SWI/SNF remodeler first engulfs a promoter nucleosome behind the replication fork. The remodeler uses energy from ATP hydrolysis to partially unwrap the nucleosome so as to expose the TF-binding motif. TFs (such as the GRFs in yeast) binding to exposed sequence motifs within unwrapped nucleosomes trap the nucleosome in a partially unwrapped state, but the unstable nucleosome is eventually displaced. TFs binding to non-nucleosomal DNA have short dwell-time, and a new nucleosome is deposited, occluding the site for a displaced TF, thus constituting a dynamic cycle.