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Ability of FD-22a to decrease the inflammatory phenotype of LPS + TNFα–stimulated HMC3 by the modulation of CB2R. Bars represent the release (pg/mL) of IL-6 (A) and IL-10 (B) in the presence of the drugs at the indicated concentrations. Data represent means ± S.E.M. from n = 3 independent experiments performed in duplicate. Statistical analysis was performed by ordinary one-way ANOVA followed by Tukey’s multiple comparison test.*p < 0.05, **p < 0.01 and ***p < 0.001.
