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. 2022 Jul 18;65(14):9918–9938. doi: 10.1021/acs.jmedchem.2c00582

Scheme 3. Synthetic Pathway for the Synthesis of Compounds FD-22a-FD-31a.

Scheme 3

Reagents and conditions: (i) CuSO4·5H2O, sodium ascorbate, DMF/H2O 4:1, 80 °C, 2 h.