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. Author manuscript; available in PMC: 2023 May 9.
Published in final edited form as: ACS Catal. 2022 Nov 14;12(23):14559–14570. doi: 10.1021/acscatal.2c04232

Scheme 1. The Stc2-catalyzed stachydrine N-demethylation reaction.

Scheme 1.

a), The Stc operon from S. meliloti 1021 and the proposed Stc2-catalyzed N-demethylation reaction using its biological reductases Stc3 and Stc4. b), Stc2-catalyzed N-demethylation reaction using a photo-reduction system with the help of photo-sensitizers (PS). c), The overall structure of Stc2 trimer. d), Stc2 active site, including its mononuclear non-heme iron site, the Rieske-type [2Fe-2S]2+ cluster on an adjacent subunit, and Glu201 used to link them.