Fig. 1.

MRS Acquisition Volume Prescription and Data Quality From a Representative AUD Patient. Panel A features two sagittal (upper) and one transverse (lower) T1w MRI of the human brain showing position of the 8x8 subarray (“excitation box”; white-border) from which usable spectra are acquired within the 16x16 proton magnetic resonance spectroscopy (MRS) voxel grid (yellow). MRS was acquired with stimulated-echo acquisition mode (STEAM; TR/TE/TM=2000/20/10 ms, voxels 10x10x10 mm3, 4 excitation). A sample voxel from the dorsal anterior cingulate cortex (dACC) target volume-of-interest (VOI) is indicated. Panel B shows raw (red) and fit (green) spectra across the excitation grid with the spectrum from the sample voxel blown-up in Panel C. NAA=N-acetyl-compounds, Cr=creatine-compounds, Cho=choline-compounds, mI=myo-inositol.