Table 2. Clinical and laboratory findings in patients with Zika virus–associated Multiple Sclerosis-like manifestations.

Clinical presentation	Patient 1	Patient 2	Patient 3	Patient 4
Age	30	51	48	57
Sex	Male	Male	Male	Female
Medical history	EM	None	None	None
Viral prodrome	Fever and myalgia	Acute fever and rash	Acute fever and rash	Fever, intense myalgia, and skin rash
Neurologic symptoms	Acute encephalomyelitis with drowsiness, mental confusion, locomotor disorders and diplopia. ADEM	Paraparesis, that evolved into tetraparesis. ADEM	Agitation and disorientation preceded, acute encephalomyelitis	Visual loss and walking impairment
Time from viral prodrome to neurologic symptoms	5 days	11 days	10 days	11 days
Neurologic examination	Hypoesthesia right upper limb and papillitis,	Dysarthria, tetraparesis and drowsiness	Tetraparesis, disorientation and decreased consciousness level	Spastic symmetric crural paraplegia, papilemema, left visual loss
Diagnostic studies
ZikV RT-PCR	Negative	Negative	Negative	Positive
Igm ZikV	Positive in the serum and urine	Positive in the serum	Positive in the serum	Positive in the serum
Igg ZikV	Positive in the serum, urine and LCR	Positive in the serum	Positive in the serum	Negative in the serum
CSF	8 leukocyte/mm 3 , 27 mg/dl protein, OCB positive, IgG index 0,88	0 leukocytes/mm 3 , 27 mg/dl protein.	15 leukocytes/mm 3 , 71 mg/dL protein, and 55 mg/dL glucose	9 leukocyte/mm 3 , 64 mg/dl protein, OCB negative, AQP4 Ab Negative