Comparison 3. Cytisine vs varenicline.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Abstinence at longest follow‐up	2	2131	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.66, 1.05]
3.2 Nausea	2	2017	Risk Ratio (M‐H, Fixed, 95% CI)	0.41 [0.33, 0.50]
3.3 Abnormal dreams	2	2017	Risk Ratio (M‐H, Fixed, 95% CI)	0.60 [0.50, 0.73]
3.4 Insomnia	2	2017	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.73, 1.10]
3.5 Headache	2	2017	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.79, 1.33]
3.6 Depression	1	679	Risk Ratio (M‐H, Fixed, 95% CI)	3.04 [0.12, 74.47]
3.7 Suicidal ideation	2	2017	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.01, 8.02]
3.8 SAEs	2	2017	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.44, 1.03]