Comparison 9. Varenicline vs bupropion.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
9.1 Abstinence at longest follow‐up	9	7560	Risk Ratio (M‐H, Fixed, 95% CI)	1.36 [1.25, 1.49]
9.2 Nausea	4	5808	Risk Ratio (M‐H, Fixed, 95% CI)	2.46 [2.20, 2.75]
9.3 Insomnia	6	6789	Risk Ratio (M‐H, Fixed, 95% CI)	0.84 [0.75, 0.93]
9.4 Abnormal dreams	4	5808	Risk Ratio (M‐H, Fixed, 95% CI)	1.56 [1.39, 1.76]
9.5 Headache	3	4888	Risk Ratio (M‐H, Fixed, 95% CI)	1.24 [1.06, 1.45]
9.6 Depression	2	4210	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.35, 2.35]
9.7 Suicidal ideation	2	4210	Risk Ratio (M‐H, Fixed, 95% CI)	1.99 [0.18, 21.93]
9.8 SAEs	5	5317	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.61, 1.31]
9.9 Neuropsychiatric SAEs (not deaths)	2	866	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.16, 7.04]
9.10 Cardiac SAEs, including deaths	2	866	Risk Ratio (M‐H, Fixed, 95% CI)	3.17 [0.33, 30.18]