Yang 2016.

Study characteristics
Methods	Country: China Setting: hospital Study design: parallel randomised trial
Participants	78 male smokers, motivated to quit, with a diagnosis of COPD  Mean age 58, baseline average CPD 5
Interventions	No medication Varenicline 2 x 1 mg/day
Outcomes	PA at 24 weeks. Self‐reported
Notes	New for 2022 update Study funding: not reported Author declaration of interests: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Stated randomised but methods not reported
Allocation concealment (selection bias)	Unclear risk	Concealment not reported
Blinding (performance bias and detection bias) All outcomes	High risk	Not placebo‐controlled
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Attrition rate unclear
Selective reporting (reporting bias)	Unclear risk	Protocol unavailable