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. 2023 May 5;2023(5):CD006103. doi: 10.1002/14651858.CD006103.pub8

ChiCTR1900021400.

Study name Individual tobacco cessation research based on nicotine metabolite ratio in smoking patients with chronic obstructive pulmonary disease: a randomized controlled trial 
Methods Parallel‐group RCT
Participants 224 participants aged 18‐85 years who meet the diagnostic criteria for both COPD and tobacco dependency, who have been smoking for > 5 years, with at least 10 CPD for the past 12 months. Exhaled CO > 10 ppm
Interventions
  • Varenicline

  • Bupropion

Outcomes Smoking abstinence rate. Nicotine metabolite ratio
Starting date 18 February 2019
Contact information Xiao Dan, +86138111374263, danxiao@263.net
Notes Study funding: The China‐Japan Friendship Hospital