NCT01800019.

Study name	The Canadian HIV Quit Smoking Trial: tackling the co‐morbidities of depression and cardiovascular disease in HIV+ smokers (CANQUIT)
Methods	Open‐label, 4‐arm, factorial RCT
Participants	256 adults who are HIV+ and smoke, 5+ CPD, willing to set a quit date
Interventions	NRT NRT + HIV‐tailored quit smoking counselling Varenicline Varenicline + HIV‐tailored quit smoking counselling
Outcomes	7‐day PPA and 4‐week CA at week 48, CO‐verified
Starting date	January 2014
Contact information	Louise Balfour, PhD, Ottawa Hospital Research Institute
Notes	Study funding: CIHR Research Operating Grant