NCT04604509.

Study name	PISCES I: Precision implemented smoking cessation evaluation study
Methods	Parallel‐group, open‐label RCT
Participants	2010 participants, > 18 years, smoking > 5 CPD, motivated to quit
Interventions	Varenicline daily for 6 weeks  NRT for 6 weeks Participants continue to receive varenicline as in group I or NRT as in group II for 6 additional weeks Participants switch to a different therapy and receive varenicline or NRT for 6 additional weeks (depending on which group originally assigned to) Higher‐dose varenicline or NRT Varenicline or NRT, plus bupropion Varenicline plus NRT All groups have behavioural counselling
Outcomes	Primary: EoT 7‐day PPA, expired CO, abstinence at 12 weeks
Starting date	04 August 2020
Contact information	Paul Cinciripini, 713‐745‐3822, pcinciri@mdanderson.org
Notes	Study funding: MD Anderson Cancer Center, National Cancer Institute