NCT05102123.

Study name	PREVENT: PeRiopEratiVE smokiNg cessaTion Trial
Methods	2x2 factorial, RCT
Participants	1720 participants, > 18 years, scheduled to undergo surgery within 28 days, currently smoking (> 100 cigarettes over lifetime and smoke every day in last 30 days)
Interventions	Cytisine and text messaging behavioural support Placebo and text messaging behavioural support Cytisine only Placebo only
Outcomes	Primary: complete abstinence from quit date to 6 months post‐randomisation, verified by exhaled CO < 10 ppm
Starting date	01 April 2022
Contact information	Emily Di Sante, 905‐297‐3479, emily.disante@phri.ca Jessica Vincent, 905‐297‐3479 ext 40635, jessica.vincent@phri.ca
Notes	Study funding: Population Health Research Institute