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. 2023 Mar 24;6(2):104–113. doi: 10.31662/jmaj.2023-0009

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Figure 1. — Overview of the miRNA biogenesis pathway in mammalian cells.

The canonical miRNA biogenesis pathway includes multiple steps, including the transcription of pri-miRNAs, DROSHA-mediated processing in the nucleus, export to the cytoplasm, DICER-mediated processing in the cytoplasm, loading onto AGO proteins, and RISC formation. Several sources of noncanonical miRNAs that are generated independently of DROSHA or DICER are known. Erythrocyte-specific miR-451 is generated via the cluster assistance mechanism of DROSHA processing and DICER-independent AGO2-mediated processing.