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. 2022 Aug 11;146(2):507–518. doi: 10.1093/brain/awac294

Figure 5.

Figure 5

RNA splicing in Mayo Clinic RNA-seq samples. Proportion of spliced reads in cerebellum samples for PSEN2 (A) exon 9B, and (B) 77 bp intron retention product or exon 6 skipping. Proportion of spliced reads in temporal cortex samples for PSEN2 (C) exon 9B, and (D) 77 bp intron retention or exon 6 skipping products. PSP = progressive supranuclear palsy. P-values were determined by a one-way ANOVA, followed by Tukey’s multiple comparisons. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. All bars are mean and standard deviation. Sporadic Alzheimer’s disease (AD) n = 82, control n = 76, pathological ageing n = 25, progressive supranuclear palsy n = 81 for cerebellum samples. Sporadic AD n = 82, control n = 74, pathological ageing n = 28, progressive supranuclear palsy n = 80 for temporal cortex samples.