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. 2022 Aug 11;146(2):507–518. doi: 10.1093/brain/awac294

Figure 6.

Figure 6

RNA editing in PSEN2 3′ UTR. (A) Schematic showing two 3′ UTRs identified for PSEN2, short (without Alu elements) and long (with Alu elements). (B) Percentage of A-to-I editing of the AluJb and AluY sites, across cohorts. Sporadic Alzheimer’s disease (AD) n = 7, PSEN variant carrier n = 7, control n = 6. (C) Level of RNA editing in Alu elements in the PSEN2 3′ UTR. P-values were determined by a one-way ANOVA, followed by Tukey’s multiple comparisons. *P < 0.05, ****P < 0.0001. All bars are mean and standard deviation. Sporadic Alzheimer’s disease n = 82, control n = 76, pathological ageing n = 25, progressive supranuclear palsy n = 81. (D) Examples of individual reads with several edits (circled horizontally) and individual residues with multiple edits (circled vertically).