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. 2022 Mar 7;146(2):645–656. doi: 10.1093/brain/awac092

Figure 1.

Figure 1

Flow diagram of the MS-PRS derivation. The post-QC discovery IMSGC summary statistics were used to construct a predictive model of multiple sclerosis risk. Multiple genetic models comprising significant variants and their associated effect sizes were optimized over a range of parameters using LDpred2. Performance of genetic models was validated in the UKBB1 and independently tested in UKBB2 and KPNC datasets.