Table 2.
Risk model improvement upon PRS addition in UKBB2 and KPNC datasets
| Prediction model | AUC (95% CI) | NRI (95% CI) | IDI (95% CI) | P a |
|---|---|---|---|---|
| UKBB2 | ||||
| ȃsex + age | 0.64 (0.62–0.65) | NA | NA | NA |
| ȃsex + age + PRS | 0.77 (0.75–0.78) | 0.729 (0.67–0.788) | 0.007 (0.006–0.008) | <0.001 |
| ȃsex + age + HLA.DRB1*15:01 (rs3135391) | 0.69 (0.68–0.71) | 0.47 (0.407–0.533) | 0.002 (0.002–0.003) | <0.001 |
| ȃsex + age + mono | 0.64 (0.63–0.66) | NA | NA | NA |
| ȃsex + age + mono + PRS | 0.77 (0.75–0.78) | 0.727 (0.668–0.786) | 0.007 (0.006–0.008) | <0.001 |
| ȃsex + age + mono + smoking | 0.65 (0.64–0.67) | NA | NA | NA |
| ȃsex + age + mono + smoking + PRS | 0.78 (0.76–0.79) | 0.726 (0.667–0.785) | 0.007 (0.007–0.008) | <0.001 |
| ȃsex + age + mono + smoking + BMI | 0.66 (0.64–0.67) | NA | NA | NA |
| ȃsex + age + mono + smoking + BMI + PRS | 0.77 (0.76–0.79) | 0.719 (0.658–0.781) | 0.007 (0.006–0.008) | <0.001 |
| KPNC | ||||
| ȃsex + age | 0.62 (0.58–0.65) | NA | NA | NA |
| ȃsex + age + PRS | 0.80 (0.77–0.83) | 0.838 (0.718–0.958) | 0.238 (0.21–0.266) | <0.001 |
| ȃsex + age + HLA.DRB1*15:01 (rs3135391) | 0.72 (0.68–0.75) | 0.64 (0.517–0.762) | 0.104 (0.083–0.124) | <0.001 |
| ȃsex + age + mono | 0.62 (0.58–0.65) | NA | NA | NA |
| ȃsex + age + mono + PRS | 0.80 (0.77–0.83) | 0.859 (0.74–0.978) | 0.238 (0.21–0.266) | <0.001 |
| ȃsex + age + mono + smoking | 0.64 (0.60–0.67) | NA | NA | NA |
| ȃsex + age + mono + smoking + PRS | 0.81 (0.78–0.84) | 0.874 (0.756–0.993) | 0.234 (0.206–0.262) | <0.001 |
| ȃsex + age + mono + smoking + family history | 0.67 (0.63–0.70) | NA | NA | NA |
| ȃsex + age + mono + smoking + family history + PRS | 0.82 (0.79–0.85) | 0.844 (0.725–0.964) | 0.214 (0.187–0.241) | <0.001 |
| ȃsex + age + mono + smoking + family history + PRS + PRS*family history | 0.82 (0.80–0.85) | 0.813 (0.692–0.933) | 0.222 (0.195–0.25) | 0.001 |
| ȃsex + age + mono + smoking + family history + overweight as a child | 0.67 (0.64–0.71) | NA | NA | NA |
| ȃsex + age + mono + smoking + family history + overweight as a child + PRS | 0.82 (0.80–0.85) | 0.844 (0.725–0.964) | 0.212 (0.185–0.239) | <0.001 |
| ȃsex + age + mono + smoking + family history + overweight as a child + BMI | 0.71 (0.68–0.75) | NA | NA | NA |
| ȃsex + age + mono + smoking + family history + overweight as a child + BMI + PRS | 0.83 (0.80–0.86) | 0.814 (0.687–0.941) | 0.184 (0.157–0.211) | 0.001 |
| ȃsex + age + mono + smoking + family history + overweight as a child + BMI20 | 0.68 (0.60–0.75) | NA | NA | NA |
| ȃsex + age + mono + smoking + family history + overweight as a child + BMI20 + PRS | 0.85 (0.79–0.92) | 1.051 (0.805–1.297) | 0.202 (0.142–0.262) | <0.001 |
Basic models are shown in bold. NA = not applicable; BMI = body mass index; BMI20 = BMI at 20; mono = mononucleosis infection.
Significance of AUC difference, NRI and IDI.