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. 2023 May 10;2023(5):CD014682. doi: 10.1002/14651858.CD014682.pub2

3. Top‐ranked antidepressants for substantial pain relief.

Antidepressant Odds ratio
(95% CI)
Mean rank Credible intervals
2.5% 97.5%
Duloxetine standard dose 1.91
(1.69 to 2.17)
8.3 5 12
Duloxetine high dose 1.91
(1.66 to 2.21)
8.5 5 12
Milnacipran high dose 1.64
(1.04 to 2.58)
10.9 4 19
Esreboxetine standard dose 1.72
(1.13 to 2.62)
11.0 4 19
Milnacipran standard dose 1.65
(1.28 to 2.13)
11.8 6 18
Mirtazapine standard dose 1.30
(0.79 to 2.15)
15.4 6 21
Duloxetine low dose 1.71
(1.36 to 2.20)
15.7 11 20
Esreboxetine high dose 1.29
(0.79 to 2.11)
15.7 7 22
Desvenlafaxine high dose 1.19
(0.83 to 1.70)
16.8 11 21
CI: confidence interval