32. Overview of all interventions in the withdrawal analysis.
| Treatment | RCTs | Participants |
| Antidepressants with ≥ 200 participants | ||
| Amitriptyline | 34 | 1326 |
| Desipramine | 4 | 230 |
| Desvenlafaxine | 2 | 885 |
| Duloxetine | 45 | 6082 |
| Esreboxetine | 2 | 978 |
| Imipramine | 5 | 240 |
| Milnacipran | 17 | 3090 |
| Mirtazapine | 3 | 269 |
| Nortriptyline | 7 | 374 |
| Paroxetine | 9 | 389 |
| Venlafaxine | 6 | 409 |
| Antidepressants with < 200 participants (excluded from summaries) | ||
| Amitriptyline + fluoxetine | 1 | 31 |
| Amitriptyline + fluphenazine | 1 | 12 |
| Amitriptyline + naproxen | 1 | 19 |
| Amitriptyline + psychotherapy | 1 | 26 |
| Amitriptyline + splint | 1 | 24 |
| Amitriptyline + support | 1 | 26 |
| Bupropion | 1 | 54 |
| Citalopram | 4 | 76 |
| Clomipramine | 2 | 124 |
| Cognitive behavioural therapy and milnacipran | 1 | 20 |
| Cognitive behavioural therapy and amitriptyline | 1 | 12 |
| Coping skills training + sertraline | 1 | 28 |
| Desipramine + cognitive behavioural therapy | 1 | 37 |
| Desipramine + lidocaine | 1 | 34 |
| Dothiepin | 2 | 55 |
| Doxepin | 1 | 30 |
| Escitalopram | 3 | 86 |
| Fluoxetine | 6 | 140 |
| Fluphenazine | 1 | 13 |
| Gabapentin + nortriptyline | 1 | 56 |
| Maprotiline | 3 | 98 |
| Melatonin + amitriptyline | 1 | 21 |
| Mianserin | 2 | 109 |
| Moclobemide | 1 | 43 |
| Morphine + nortriptyline | 1 | 55 |
| Nortriptyline + cognitive behavioural therapy | 1 | 41 |
| Nortriptyline + disease management | 1 | 37 |
| Nortriptyline + morphine | 1 | 52 |
| Pirlindole | 1 | 45 |
| Pregabalin + duloxetine | 1 | 41 |
| Pregabalin + imipramine | 1 | 73 |
| Reboxetine | 1 | 18 |
| Sertraline | 2 | 66 |
| Trazodone | 3 | 63 |
| Trazodone + gabapentin | 2 | 94 |
| Trimipramine | 1 | 18 |
| Zimeldine | 1 | 17 |
| Non‐antidepressant interventions (excluded from summaries) | ||
| ABT‐894 | 1 | 172 |
| Acetaminophen (paracetamol) | 1 | 50 |
| Acupuncture | 1 | 24 |
| Aerobic exercise | 1 | 20 |
| Carbamazepine | 2 | 99 |
| Cognitive behavioural therapy | 7 | 333 |
| Coping skills training | 1 | 29 |
| Cyclobenzaprine | 1 | 42 |
| Disease management | 1 | 24 |
| Education | 1 | 71 |
| Gabapentin | 6 | 269 |
| Lamotrigine | 1 | 53 |
| Lidocaine | 1 | 33 |
| Melatonin | 1 | 21 |
| Morphine | 2 | 107 |
| Naltrexone | 1 | 67 |
| Naproxen | 1 | 19 |
| Neurofeedback | 1 | 20 |
| Panax ginseng | 1 | 19 |
| Physical therapy | 1 | 34 |
| Pregabalin | 9 | 919 |
| Psychotherapy | 2 | 116 |
| Saffron/crocin | 2 | 53 |
| Support | 1 | 24 |
| TENS | 1 | 50 |
| Terbutaline | 1 | 51 |
| Usual treatment | 1 | 70 |
| Waitlist | 1 | 24 |
|
RCT: randomised controlled trial; TENS: transcutaneous electrical nerve stimulation Participant numbers reflect the total number of participants receiving the antidepressant. | ||