Engel 1998.

Study characteristics
Methods	Design: cross‐over Duration: 15 weeks (6 weeks per cross‐over period) Assessment: baseline and post‐intervention Country: USA
Participants	Pain condition: pelvic pain Population: women with chronic pelvic pain Minimum pain intensity: no Inclusion criteria Aged 18‐50 Pelvic pain persisting for ≥ 3 months Exclusion criteria Laparoscopy within the last 3 months Total participants randomised: 25 Age in years (mean, SD): 29.0 (7.2) Gender: 25/25 were female Pain duration in years (mean, SD): NR
Interventions	Placebo n = 25 Inert Sertraline 100 mg n = 25 SSRI Fixed dose, 50 mg taken twice daily
Outcomes	No useable data were able to be extracted from the study.
Missing data methods	Completer analysis only
Funding source	NR
Conflicts of interest	NR
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomisation methods not specified
Allocation concealment (selection bias)	Unclear risk	Allocation procedures not specified
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No information on blinding procedures
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Self‐reported outcomes but unsure of blinding procedures
Incomplete outcome data (attrition bias) All outcomes	Low risk	Completer analysis but low dropout Attrition Total: 2/25 (8%) Attrition per arm NR
Selective reporting (reporting bias)	Unclear risk	No protocol or trial registration found
Other bias	Low risk	No other sources of bias identified