Grace 1985.

Study characteristics
Methods	Design: parallel Duration: 12 weeks Assessment: baseline, 4 weeks, 8 weeks, and post‐intervention Country: Canada
Participants	Pain condition: RA Population: adults with RA Minimum pain intensity: no Inclusion criteria Patients with 'definite' or 'classical' RA, as defined by the ACR criteria Exclusion criteria: NR Total participants randomised: 36 Age in years (mean, range): 58 (27‐76) Gender: 29/36 were female Pain duration in years (mean, SD): NR
Interventions	Placebo n = 18 Inert Identical appearance to antidepressants Amitriptyline 50‐75 mg n = 18 TCA Flexible doses dependent upon tolerability
Outcomes	Withdrawal
Missing data methods	Completer‐only analysis
Funding source	NR
Conflicts of interest	NR
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomisation methods not specified
Allocation concealment (selection bias)	Unclear risk	Allocation procedures not specified
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blind, identical tablets with matched dosing
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Self‐reported outcomes by blinded participants
Incomplete outcome data (attrition bias) All outcomes	High risk	Completer analysis only Attrition Total: 8/36 (22.2%) Placebo: 4/18 (22.2%) Amitriptyline 50‐75 mg: 4/18 (22.2%)
Selective reporting (reporting bias)	Unclear risk	No protocol or trial registration found
Other bias	Low risk	No other sources of bias were identified.