Vahedi 2005.

Study characteristics
Methods	Design: parallel Duration: 12 weeks Assessment: baseline, post‐intervention, follow‐up (4 weeks post‐intervention) Country: Iran
Participants	Pain condition: IBS Population: people with pain and constipation‐predominant IBS Minimum pain intensity: no Inclusion criteria People with pain and constipation‐predominant IBS as defined by the Rome II criteria were included Exclusion criteria Physical and severe mental health comorbidities Total participants randomised: 44 Age in years (mean, SD): 34.9 (10.0) Gender: 27/44 were female Pain duration in years (mean, SD): NR
Interventions	Placebo n = 22 Inert Identical appearance to fluoxetine, matched dosing Fluoxetine 20 mg n = 22 SSRI Fixed dose
Outcomes	Withdrawal
Missing data methods	No participants withdrew
Funding source	Non‐pharmaceutical: This study was supported by a grant from the Digestive Disease Research Center of Tehran University of Medical Sciences.
Conflicts of interest	NR
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Patients were randomly assigned according to a computer‐generated randomisation table
Allocation concealment (selection bias)	Unclear risk	Allocation procedures NR
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blind, identical study drugs, matched dosing
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Self‐reported outcomes by blinded participants
Incomplete outcome data (attrition bias) All outcomes	Low risk	No participants withdrew
Selective reporting (reporting bias)	Unclear risk	No protocol or trial registration found
Other bias	Low risk	No other sources of bias were identified.