ACTRN12620000656932.

Methods	Double‐blind, parallel‐arm, placebo‐controlled RCT
Participants	Unclear from trial registration whether this is acute or chronic pain Inpatients and outpatients with diagnoses of cancer and neuropathic pain (probable or definite neuropathic pain by IASP criteria) Pain related to cancer with a worst pain score of ≥ 4 on BPI item 3 (worst pain intensity) score in the past 24 h Neuropathic Pain on LANSS ≥ 12 Taking stable regular analgesics within 72 hours before commencing on the study. Target: 160
Interventions	Duloxetine 30/day orally for 7 days, then increase to 60 mg/day for 7 days, then downward titrate to 30 mg/day for 7 days Pregabalin 50/day orally for 3 days, 150 mg/day for 4 days, then 300 mg/day for 7 days, then downward titration to 150 mg/day for 4 days, and 50 mg/day for 3 days
Outcomes	Pain intensity Anxiety Depression Daily opioid use
Notes