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Cohorts, controls, TMB and ID ratio. A Numbers of samples by cohort. Four ICGC samples with CHEK2 mutations other than c.1100delC were excluded from the dataset and subsequent analyses. B Results of samples analyzed on both HMF and ICGC pipelines. *only 17 SVs and **only 18 DBS for signature calling. Distributions of C TMB and D ID ratio by group. Horizontal line shows median TMB. P-values are from Kruskal–Wallis comparison of the primary BC subgroups
