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Mutational signatures in primary BC subgroups. A Cosine similarity coefficients (top) and hierarchical clustering (bottom) of BC subgroups based on the median % relative contribution of 40 SBS, DSB, ID and SV signatures. Percentage relative contribution of mutational signatures associated with the HRD phenotype: B SBS3, C SBS8, D ID6, and signatures associated with E BRCA1 (SV3) and F BRCA2 (SV5). P-values are based on Mann–Whitney test
