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. 2023 May 9;20:19. doi: 10.1186/s12979-023-00347-7

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — A Heat map illustrating baseline correlations. Pearson’s r values are depicted, where the values are given in the coloured scale bar. B Absolute change in BMI and HOMA-IR per study group over the twelve-week intervention period (Δ = t₁₂—t₀). *(p < .05) indicates a significant difference between groups, analysed by rmANCOVA. CON = control group; EX (two-group-comparison) = exercise group (with and without nutrition instructions); EX (three-group-comparison) = exercise group without nutrition instructions; EX + NUTR = exercise group with nutrition instructions; BMI = Body-Mass-Index, HOMAi = HOMA-Index; EMRA CD8 + = Effector Memory re-expressing CD45RA CD8 + cells; TRP = tryptophane; KYN = kynurenine; QA = quinolinic acid; KA = kynurenic acid