Table 2.
Correlations between PPFIA1 protein expression and clinicopathological variables in 147 patients with ESCC from the TMA dataset
| Clinicopathological variables | Number | PPFIA1 expression | x2 | P value | |
|---|---|---|---|---|---|
| Low | High | ||||
| Gender | < 0.001 | 0.983 | |||
| Male | 119 | 38 (31.9%) | 81 (68.1%) | ||
| Female | 28 | 9 (32.1%) | 19 (67.9%) | ||
| Age(years) | 1.433 | 0.231 | |||
| ≤ 68 | 77 | 28 (36.4%) | 49 (63.6%) | ||
| ˃68 | 70 | 19 (27.1%) | 51 (72.9%) | ||
| Smoking use | 3.280 | 0.070 | |||
| None | 77 | 20 (26.0%) | 57 (74.0%) | ||
| Yes | 70 | 28 (40.0%) | 42 (60.0%) | ||
| Tumor location | 9.067 | 0.011 | |||
| Upper | 6 | 0 (0) | 6 (100.0%) | ||
| Middle | 123 | 37 (30.1%) | 86 (69.9%) | ||
| Lower | 18 | 10 (55.6%) | 8 (44.4%) | ||
| Tumor size (cm) | 0.803 | 0.370 | |||
| < 3.5 | 61 | 22 (36.1%) | 39 (63.9%) | ||
| ≥ 3.5 | 86 | 25 (29.1%) | 61 (70.9%) | ||
| Histological grade | 1.565 | 0.457 | |||
| I | 11 | 5 (45.5%) | 6 (54.5%) | ||
| II | 115 | 37 (32.2%) | 78 (67.8%) | ||
| III | 21 | 5 (23.8%) | 16 (76.2%) | ||
| Tumor invasion depth | 6.369 | 0.041 | |||
| T1- T2 | 22 | 11 (50.0%) | 11 (50.0%) | ||
| T3 | 80 | 27 (33.8%) | 53 (66.3%) | ||
| T4 | 45 | 9 (20.0%) | 36 (80.0%) | ||
| Lymph node metastasis | 5.449 | 0.020 | |||
| None | 86 | 34 (39.5%) | 52 (60.5%) | ||
| Yes | 61 | 13 (21.3%) | 48 (78.7%) | ||
| TNM stage | 7.344 | 0.007 | |||
| I/II | 55 | 25 (45.5%) | 30 (54.5%) | ||
| III | 92 | 22 (23.9%) | 70 (76.1%) | ||
Abbreviations: PPFIA1 PTPRF interacting protein alpha 1, ESCC esophageal squamous cell carcinoma, TNM tumor-node-metastasis, TMA TMA, tissue microarray