Table 3.
PRP preparation and administration
| Author and Year | Platelet Concentration vs. Baseline Leukocyte Status |
Number of Treatments | Injection Interval | Injection Method | Pre-activation | Centrifugation Procedure | |
|---|---|---|---|---|---|---|---|
| Dose | Post-procedure management | ||||||
| Guney et al.2016 |
6.4 Not Reported |
1 | - |
4mL per time; PRP injected 6–24 h post-microfracture at time of Hemovac drain removal; |
Rehabilitation program | Not Reported | Not Reported |
| Guney et al.2015 |
6.4 Not Reported |
1 | - |
Dose unknown; PRP injected 6–24 h post-microfracture at time of Hemovac drain removal; |
Rehabilitation program | Not Reported | Not Reported |
| Görmeli et al.2015 |
5.2 Not Reported |
1 | - |
Dose unknown; PRP injected 24–36 h post-microfracture at time of Hemovac drain removal; |
Rehabilitation program | Not Reported | Not Reported |
| Paget et al.2021 | Not Reported Leukocyte-Poor | 2 | 6 weeks | 2mL | Education leaflet | Nonactivated | 1st centrifugation: 5 min; |
| Sampson S et al. 2016 |
4.2 Leukocyte-Poor |
1 | - |
1–2 cc; Bone marrow concentrate was injected intra-articular 8 weeks before PRP; |
Rehabilitation program or home exercise program | Nonactivated |
1st centrifugation: 2800 rpm for 10 min; 2nd centrifugation: 3400 rpm for 6 min; |
| Fukawa et al. 2017 |
5.1 Leukocyte-Poor |
3 | 2 weeks |
2mL per time; Ultrasound guided; |
Not reported | Calcium chloride |
1st centrifugation: 800 g for 5 min; 2nd centrifugation: 1500 g for 8 min; |
| Li et al. 2021 | Not Reported | 3 |
During surgery; 4, 12 weeks after surgery; |
5mL per time; | Not reported | Not reported |
1st centrifugation: 2000 r / min for 10 min; 2nd centrifugation: 2000 r / min for 10 min; |
| Repetto et al. 2017 |
2–3 Leukocyte-Poor |
4 | 1 week | 3mL per time; | Not reported | Not reported |
1st centrifugation: 3550 rpm for 12 min; 2nd centrifugation: 1100 rpm for 10 min; 3rd centrifugation: 2600 rpm for 20 min; |
| Akpancar et al. 2019 | Not Reported | 3 | 3 weeks |
4mL per time; 2 mL for intra-articular and 2 mL for tibial edge and talar dome adjacent to the joint surface; |
Not reported | Nonactivated | 1st centrifugation: 3200 rpm for 15 min; |
| Mei-Dan et al. 2012 | Not Reported | 3 | 2 weeks | 2mL per time; |
Avoid unnecessary walking for 24 h. Avoid sports activity or heavy physical work for 2 to 3 days after injection. Avoid nonsteroidal anti-inflammatory medications for 2 weeks after the last injection |
Calcium chloride | 1st centrifugation: 640 g for 8 min; |