Table 2.
Linear Regression of Epigenetic Age Acceleration Markers With the Veterans Aging Cohort Study Index
| EAA Marker (per Year) | Median (Minimum, Maximum) | Mean (SD) | β Estimatea | (95% CI) | P Value |
|---|---|---|---|---|---|
| HorvathAA | 0.55 (−25.12, 22.94) | 0.61 (6.23) | .14 | (−.08 to .37) | .219 |
| HannumAA | −0.15 (−23.47, 29.92) | −0.15 (5.60) | .51 | (.26–.76) | <.001 |
| IEAA | 0.05 (−24.15, 19.49) | 0.08 (5.62) | −.14 | (−.40 to .11) | .276 |
| EEAA | 0.19 (−26.10, 36.00) | 0.27 (7.11) | .56 | (.37–.75) | <.001 |
| GrimAA | −0.06 (−12.23, 14.66) | 0.02 (4.88) | 1.18 | (.91–1.45) | <.001 |
| PhenoAA | 0.58 (−32.19, 30.04) | 0.59 (8.71) | .58 | (.42–.73) | <.001 |
Abbreviations: CI, confidence interval; EAA, epigenetic age acceleration; EEAA, extrinsic epigenetic age acceleration; GrimAA, Grim age acceleration; HannumAA, Hannum DNA methylation age acceleration; HorvathAA, Horvath DNA methylation age acceleration; IEAA, intrinsic epigenetic age acceleration; PhenoAA, Pheno age acceleration; SD, standard deviation.
Per point of Veterans Aging Cohort Study Index.