Table 3.
Inverse Propensity Weighting Comparisons of Primary Endpoint (Microbiologic Failure at 90 d) by Antibiotics Strategy
| Comparison Groups | A Completed Inpatient IV [Gold standard] |
B Partial IV, No Oral |
C Partial IV, Partial Oral |
P Value |
|---|---|---|---|---|
| Comparing microbiologic failure at 90 d between patients who discharged before completing IV antibiotics (strategy B vs C) | … | 16 (44.4) [N = 36] |
9 (13.0) [N = 69] |
.001 |
| - Inverse probability weighted | … | aOR 6.7 (1.9, 25.8) | 1 (reference) | .005 |
| Comparing microbiologic failure at 90 d between patients who completed standard of care (strategy A) vs partial oral antibiotics (strategy C) | 13 (10.7) [N = 122] |
… | 9 (13.0) [N = 69] |
.8 |
| - Inverse probability weighted | 1 (reference) | … | aOR 1.3 (0.4, 3.7) | .7 |
| Subgroup analysis: Including only those with ≥10 d effective IV antibiotic therapy before discharge | ||||
| Comparing microbiologic failure at 90 d between patients who discharged before completing IV antibiotics (strategy B vs C) | … | 9 (40.9) [N = 22] |
5 (10.9) [N = 46] |
.004 |
| - Inverse probability weighted | … | aOR 5.4 (1.2, 24.0) | 1 (reference) | .03 |
| Comparing microbiologic failure at 90 d between patients who completed standard of care (strategy A) vs partial oral antibiotics (strategy C) | 13 (10.7) [N = 122] |
… | 5 (10.9) [N = 46] |
.9 |
| - Inverse probability weighted | 1 (reference) | … | aOR 1.1 (0.3, 3.9) | .9 |
Abbreviations: aOR, adjusted odds ratio; IV, intravenous.