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. 2022 Jul 22;146(2):749–766. doi: 10.1093/brain/awac266

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Top 25 pain-associated genes in the female cohort (increased in pain). Pain-associated genes in female samples (Supplementary Table 3C) show systematic increases in pain. Quantile plots (quantile versus value) for gene relative abundances (in TPMs) in the top 25 genes are shown in female pain samples (in magenta, upper line) and female no-pain samples (in green, lower line). These include multiple members of receptor genes (ADORA2B, IL1RAPL2, GPR160), pro-inflammatory and proliferation-related genes (HAMP, FREM1), vesicular trafficking genes (LYG2, RASEF) and interferon-response genes (USP6, TTC12).