Figure 1.

Pedigree of family unit examined at the NIH. The symbols with an asterisk indicate those individuals examined at the NIH. These include the patriarch and matriarch of the family, three unaffected daughters, two daughters with nodding syndrome and one grandson with nodding syndrome. Open symbols are unaffected individuals and shaded symbols are those with nodding syndrome. Circles indicate female, squares indicate males and the diamond icons indicate gender not specified. Numbers within symbol indicate the number of individuals represented by that shape and the letter ‘n’ indicates an unknown number, but more than one, of individuals being represented by that shape. Numbers outside the circle indicate age of the patient when seen at the NIH.