Figure 3.

Brain MRI findings in patients with nodding syndrome and an unaffected sibling. (A) Patient 1: (i) cerebral atrophy and mild colpocephaly; (ii) deposition of metal in globus pallidus more than typical for age; (iii) possible pituitary lesion. (B) Patient 2: (i) slight cerebral atrophy; (ii) deposition of metal in globus pallidus more than typical for age; (iii and iv) this signal change represents metal based upon the direction of the phase shift on SWI sequences. (C) Patient 3: (i) normal cerebral volume; (ii) deposition of metal in globus pallidus more than typical for age; (iii) subtle asymmetry of the hippocampi with left being smaller. (D) Unaffected sibling: (i) minimal bilateral colpocephaly; (i) deposition of metal more than typical for age in globus pallidus; (iii) deposition of metal in the substantia nigra and red nucleus; (iv) deposition of metal in the cerebellar dentate nuclei.