Figure 3.

Duration of last positivity (days) after antibiotic treatment initiation for mcfDNA and blood culture for any positive bottle (ie, blood culture set). (A) Semiparametric survival model estimation and (B) Bayesian survival model estimation. Divergence of the Bayesian survival credible intervals for blood culture (any bottle +) and mcfDNA occurred at 7.4 days (P value <0.025), demonstrated by lack of overlap between the credible intervals (outer bounds) on survival probability for mcfDNA and blood culture for any positive bottle. The number at risk below the figure indicates how many tests remain positive at that time point. Survival curves represent duration of last positivity for the causative pathogen of IE: false-positive and false-negative mcfDNA and blood cultures were treated as completely left-censored. IE, infective endocarditis; mcfDNA, microbial cell-free DNA.